What Are The Different Strengths Of Phenobarbital?

  • 15mg.
  • 16.2mg.
  • 30mg.
  • 32.4mg.
  • 60mg.
  • 64.8mg.
  • 97.2mg.
  • 100mg.

How much phenobarbital should I take for seizures?

15 to 20 mg/kg IV over 10 to 15 minutes as a single loading dose initially (Max: 1,000 mg/dose). Additional 5 to 10 mg/kg bolus doses may be given at 15- to 30-minute intervals for refractory seizures. A maximum total dose of 40 mg/kg has been recommended.

What is the therapeutic level of phenobarbital?

The therapeutic range for adults taking phenobarbital is 15-40 micrograms/milliliter (mcg/ml) (65-173 micromole/liter) for seizure treatment, and 5-15 micrograms/milliliter (mcg/ml) (22-65 micromole/liter) for sedative-hypnotic use.

How many mg are in a grain of phenobarbital?

Each phenobarbital tablet contains 16.2 mg (1/4 grain), 32.4 mg (1/2 grain), 64.8 mg (1 grain) or 97.2 mg (11/2 grain) of phenobarbital.

Is there a substitute for phenobarbital?

Carbamazepine is a suitable substitute for phenobarbital, primidone, and phenytoin, alone or in combination, when used in the treatment of generalized tonic-clonic or par- tial epilepsy.

How much does phenobarbital cost without insurance?

The lowest GoodRx price for the most common version of phenobarbital is around $17.64, 62% off the average retail price of $46.90.

Can phenobarbital cause brain damage?

Cognitive deficits in adults: Long-term use of phenobarbital is associated with a number of cognitive deficits in adults that can include similar issues with learning and memory, attention and concentration, complex attention, expressive and receptive speech, and problem-solving.

What is the toxic serum level of phenobarbital?

The therapeutic reference range of phenobarbital is 10-30 mcg/mL. The toxic reference range of phenobarbital is >40 mcg/mL.

How much phenobarbital does it take to overdose?

Phenobarbital Overdose

A lethal dose of phenobarbital is 6-10 grams, which a person may have in their medicine cabinet if they have been prescribed this drug. As a daytime sedative, a doctor may prescribe anywhere from 30 mg to 120 mg, and as an insomnia treatment, an individual could take as much as 320 mg.

What type of seizure is phenobarbital used for?

Phenobarbital is approved in the United States by the Food and Drug Administration (FDA) for add-on therapy for partial and tonic-clonic seizures. It has been used alone for more than 80 years, however, to treat partial and tonic-clonic seizures. It is also used for treatment of status epilepticus.

How long does it take for phenobarbital to kick in?

Tablets or elixirs begin to act in about 60 minutes,2 and their duration lasts for 10 to 12 hours,3 depending on the dosage and individual metabolism. The plasma half-life of phenobarbital in adults is an average of about 79 hours and 110 hours in children.

How long can you take phenobarbital?

It works by controlling the abnormal electrical activity in the brain that occurs during a seizure. This medication is also used for a short time (usually no more than 2 weeks) to help calm you or help you sleep during periods of anxiety.

What does phenobarbital do to a human?

Phenobarbital slows the activity of your brain and nervous system. Phenobarbital is used to treat or prevent seizures. Phenobarbital is also used short-term as a sedative to help you relax.

Do doctors still prescribe phenobarbital?

Phenobarbital has been used to treat epilepsy since the early decades of the 20th century. It is still commonly used throughout the world because it is both effective and low in cost.

What is the generic for phenobarbital?

Phenobarbital (Brand Name: Solfoton) is a barbiturate used to treat or prevent seizures. Phenobarbital is also used short-term to treat insomnia, or as a sedative before surgery.

Is phenytoin and phenobarbital the same?

Phenobarbital can be used for generalized and focal seizures, but it can make you feel sleepy. Treats and prevents seizures. Dilantin (phenytoin) is very good at treating and preventing seizures, but it has many drug interactions and some serious side effects. Phenobarbital is available as a generic.

Can phenytoin and phenobarbital be taken together?

phenytoin PHENobarbital

Using phenytoin together with PHENobarbital may affect your seizure control. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter phenytoin levels.

What is a normal carbamazepine level?

The therapeutic range for carbamazepine when it is taken by itself is about 4 to 12 mcg/mL (micrograms per milliliter). Levels above 15 mcg/mL are considered toxic.

Is phenobarbital hard on the kidneys?

Renal impairment

Approximately 25% of an administered dose of phenobarbital is cleared by the kidney as unchanged drug.

Is phenobarbital hard on the liver?

Phenobarbital has been linked to rare instances of idiosyncratic liver injury that can be severe and even fatal.

Does phenobarbital cause dementia?

Phenobarbital and phenytoin have good antiepileptic effect, but clinically significant untoward effects occur during their long-term use. Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent.

What is the most expensive seizure medication?

Lamotrigine ER is an expensive drug used to control seizures in adults and children with epilepsy. This drug is less popular than comparable drugs. It is available in brand and generic versions.

What is the best medication for seizures?

Many medications are used in the treatment of epilepsy and seizures, including:

  • Carbamazepine (Carbatrol, Tegretol, others)
  • Phenytoin (Dilantin, Phenytek)
  • Valproic acid (Depakene)
  • Oxcarbazepine (Oxtellar, Trileptal)
  • Lamotrigine (Lamictal)
  • Gabapentin (Gralise, Neurontin)
  • Topiramate (Topamax)
  • Phenobarbital.


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