Hodgkin’s disease and non-Hodgkin’s lymphoma (NHL) are the two major types of cancer affecting the lymphatic system (lymphoma). In contrast to NHL, Hodgkin’s disease is typically characterized by the presence of a specific type of cancer cell known as a Reed-Sternberg cell that has more than one nucleus.
Which form of cancer has the presence of Reed-Sternberg cells?
Hodgkin lymphoma is marked by the presence of Reed-Sternberg cells, which a physician can identify using a microscope. In non-Hodgkin lymphoma, these cells are not present.
Which condition would produce Reed-Sternberg cells?
Reed-Sternberg cells are large, abnormal lymphocytes (a type of white blood cell) that may contain more than one nucleus. These cells are found in people with Hodgkin lymphoma.
What is Hodgkin’s diseases?
Hodgkin disease is a type of lymphoma. Lymphoma is a cancer of a part of the immune system called the lymph system. The first sign of Hodgkin disease is often an enlarged lymph node. The disease can spread to nearby lymph nodes. Later it may spread to the lungs, liver, or bone marrow.
How are Reed-Sternberg cells identified?
Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are distinctive, giant cells found with light microscopy in biopsies from individuals with Hodgkin lymphoma. They are usually derived from B lymphocytes, classically considered crippled germinal center B cells.
What is Waldenstrom syndrome?
Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells.
Are Reed-Sternberg cells found in leukemia?
Reed-Sternberg-like cells found in low-grade B cell lymphomas are visible in follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma or marginal zone lymphoma.
Are lymphoma and leukemia the same?
The main difference between lymphocytic leukemias and lymphomas is that in leukemia, the cancer cells are mainly in the bone marrow and blood, while in lymphoma they tend to be in lymph nodes and other tissues.
What is distinguished from other lymphomas by the presence of large cancerous lymphocytes known as Reed-Sternberg cells?
A doctor can tell the difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma by examining the cancer cells under a microscope. If in examining the cells, the doctor detects the presence of a specific type of abnormal cell called a Reed-Sternberg cell, the lymphoma is classified as Hodgkin’s.
Is distinguished from other lymphomas by the presence?
Hodgkin Lymphoma is distinguished from other lymphomas primarily by the presence of giant cells known as Reed-Sternberg cells.
What is the cause Angioimmunoblastic T-cell lymphoma?
Suspected risk factors include several viruses including the Epstein-Barr virus, cytomegalovirus, hepatitis C virus, human herpes viruses 6 and 8, and the human immunodeficiency virus. Certain infectious agents including tuberculosis and Cryptococcus have also been linked to AITL.
What is the Reed-Sternberg test?
Lab tests of biopsy samples
All biopsy samples are looked at under a microscope by a pathologist (a doctor specially trained to recognize cancer cells), who will look for Hodgkin lymphoma cells (called Reed-Sternberg cells).
Why is it called Hodgkin disease?
Hodgkin’s lymphoma is a cancer of the lymphatic system that affects the B-lymphocytes, causing them to accumulate in the lymph nodes. The cancer is named after Thomas Hodgkin who first described abnormalities in the lymphatic system in 1832.
What is classic Hodgkin lymphoma?
Classical Hodgkin lymphoma is any type of lymphoma that contains a particular type of cell called a Reed–Sternberg cell. Reed–Sternberg cells are abnormal B lymphocytes (white blood cells that make antibodies, which are important in fighting infections).
Does all Hodgkin’s lymphoma have Reed-Sternberg cells?
Classical Hodgkin lymphoma is the most common form of Hodgkin lymphoma. There are 4 types and they all contain abnormal cells called Reed-Sternberg cells. These cells are a type of white blood cell (B lymphocyte) that have become cancerous.
What is Pel Ebstein fever?
Pel-Ebstein is a high-grade fever that keeps rising and falling every 7-10 days or so. The fever rises abruptly, stays high for a week or so and then falls close to normal abruptly again, staying low for about a week.
What is the difference between Waldenstrom’s and Multiple Myeloma?
Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone within the bone marrow. While the cause of myeloma is not known, interleukin 6 may play a role in driving myeloma cell proliferation. Waldenstrom’s macroglobulinemia (WM) is a proliferative disease of B-lymphocytes.
What causes Waldenstroms?
Waldenstrom’s disease develops when your body overproduces IgM antibodies. The cause of this disease is unknown. The condition is more common among people who have family members with the disease. This suggests that it may be hereditary.
What is monoclonal protein?
Listen to pronunciation. (MAH-noh-KLOH-nul PROH-teen) An antibody found in unusually large amounts in the blood or urine of people with multiple myeloma and other types of plasma cell tumors. Also called M protein.
Are Reed-Sternberg cells T cells?
Hodgkin’s and Reed–Sternberg cells of classical Hodgkin’s lymphoma are primarily of B-cell origin, although there are instances of T-cell antigen expression suggesting T-cell origin.
Why do Reed-Sternberg cells form?
Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase. PLoS One.
Are Reed-Sternberg cells found in bone marrow?
The presence of Reed-Sternberg cells in smears of bone marrow aspirate or imprints of lymph nodes, spleen, liver, and bone mar- row, as well as in tissue sections of involved organs, permits the diagnosis of Hodgkin’s disease.
What are the types of Hodgkin lymphoma?
Types of Hodgkin lymphoma
- Nodular sclerosis Hodgkin lymphoma or NSCHL: This is the most common type of Hodgkin disease in developed countries. …
- Mixed cellularity Hodgkin lymphoma or MCCHL: This is the second most common type, found in about 4 out 10 cases. …
- Lymphocyte-rich Hodgkin lymphoma: This sub-type isn’t common.