Mitomycin C is a vesicant chemotherapeutic agent used to treat solid tumors. Its ability to cause delayed and remote tissue injury after intravenous administration is reported in the literature.
How do you use mitomycin injection?
In cytostatic monochemotherapy mitomycin is usually administered intravenously as a bolus injection. The recommended dosage is 10 – 20 mg/m2 of body surface every 6 – 8 weeks, 8 – 12 mg/m2 of body surface every 3 – 4 weeks or 5-10 mg/m2 of body surface every 1-6 weeks, depending on the therapeutic scheme used.
How do you administer mitomycin?
Mitomycin is given directly into the bladder (called intravesicular), through a catheter, and left in the bladder for 1-2 hours. The dosage and schedule is determined by your healthcare provider. This drug is blue in color and may make your urine blue-green in color. This can last up to two days after each dose.
Can mitomycin be given IV?
In cytostatic monochemotherapy mitomycin is usually administered intravenously as a bolus injection. The recommended dosage is 10 – 20 mg/m2 of body surface every 6 – 8 weeks, 8 – 12 mg/m2 of body surface every 3 – 4 weeks or 5-10 mg/m2 of body surface every 1-6 weeks, depending on the therapeutic scheme used.
How is mitomycin ophthalmic administered?
Mitomycin ophthalmic is a liquid medicine that is applied first to a tray of tiny sponges. The sponges will soak in the mitomycin for at least 60 minutes. Once the sponges are saturated with mitomycin, your surgeon will place the sponges directly onto your eye.
How often is Mitomycin given?
How is Mitomycin-C treatment given? Mitomycin-C is inserted directly into your bladder through a fine tube (catheter) to treat the entire lining of your bladder. The treatment usually involves coming to hospital once a week for six weeks as an outpatient.
Why is etoposide called VP 16?
Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug (von Wartburg) and podophyllotoxin.
What is Mitomycin injection used for?
MITOMYCIN (mye toe MYE sin) is a chemotherapy drug. This medicine is used to treat cancer of the stomach and pancreas.
What is the difference between mitomycin and BCG?
The overall analysis revealed a significant benefit of BCG compared with mitomycin C in terms of 5-year PFS rate (odds ratio, 0.53; 95% confidence interval, 0.38–0.75; P<0.001), indicating that BCG was superior to mitomycin C therapy in patients with non-muscle invasive bladder cancer following transurethral resection.
What is MMC surgery?
Mitomycin C (MMC) is an antimetabolite used during the initial stages of a trabeculectomy to prevent excessive postoperative scarring and thus reduce the risk of failure.
Is cisplatin a vesicant?
Physicians should be aware that cisplatin, even at low concentrations, has vesicant potential and should be administered with appropriate care.
Is mitomycin a biologic?
Mitomycin C (MC) is a naturally occurring anticancer agent which has been shown to be more cytotoxic to hypoxic tumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involve biological reductive activation, to a species that alkylates DNA.
Why do you have to flush the toilet twice after chemo?
It takes about 48 hours for your body to break down and get rid of most chemo drugs. When chemo drugs get outside your body, they can harm or irritate skin – yours or even other people’s. Keep in mind that this means toilets can be a hazard for children and pets, and it’s important to be careful.
Is BCG an immunotherapy?
Bacillus Calmette-Guerin or BCG is the most common intravesical immunotherapy for treating early-stage bladder cancer. It’s used to help keep the cancer from growing and to help keep it from coming back. BCG is a germ that’s related to the one that causes tuberculosis (TB), but it doesn’t usually cause serious disease.
What is the strongest chemotherapy?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.
What is Adriamycin used for?
Adriamycin PFS (doxorubicin hydrochloride) Injection is a cancer (antineoplastic) medication used to treat many types of cancer. The brand name Adriamycin PFS is discontinued in the U.S. Generic forms may be available.
Is etoposide platinum based?
The cornerstone of treatment for any stage of SCLC is etoposide-platinum based chemotherapy; in limited stage (LS), concomitant radiotherapy to thorax and mediastinum.
What is Mitomycin instillation?
Mitomycin-C is a type of antibiotic that is only used in cancer therapy. It slows or stops the growth of cancer cells in your body. Mitomycin-C is a clear blue or purple liquid. For the therapy, we put this liquid into the bladder using a catheter (tube).
How long does 5 fluorouracil stay in your system?
The chemotherapy itself stays in the body within 2 -3 days of treatment but there are short-term and long-term side effects that patients may experience. Not all patients will experience all side effects but many will experience at least a few.
When is mitomycin C used?
Its use and application in ophthalmology has been increasing in recent years because of its modulatory effects on wound healing. Current applications include pterygium surgery, glaucoma surgery, corneal refractive surgery, cicatricial eye disease, conjunctival neoplasia and allergic eye disease.
How is mitomycin C prepared for trabeculectomy?
To prepare the MMC injection, the surgeon used a 20-ug preparation starting with MMC 0.4 mg/mL, diluting 0.1 mL of MMC (40 μg) in 0.1 mL of lidocaine (1:1, total volume of 0.2 mL). Half of that solution (0.1 mL of MMC:lidocaine ) was used for injection. Topical anesthesia was instilled.
How do you make mitomycin eye drops?
Our preparation of the mitomycin-C includes mixing the drug with a sterile water diluent to achieve a starting concentration of 0.2 mg/ml. This is then diluted further with 2% lidocaine—the same lidocaine we would use in a retrobulbar block.
How is a trabeculectomy performed?
When performing trabeculectomy, an eye surgeon creates a flap in the sclera — the white part of the eye — underneath the upper eyelid. Underneath this flap, a pathway is created to allow fluid to drain, which lowers eye pressure.