How does doxorubicin cause cardiotoxicity?
Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.
Why does doxorubicin affect the heart?
Doxorubicin appears to induce toxic damage to the mitochondria of cardiomyocytes. Several mitochondrial enzymes such as NADH dehydrogenase, cytochrome P-450 reductase and xanthine oxidase are involved in generating oxygen free radicals (reactive oxygen species) .
Which is the most serious side effect of doxorubicin >?
This medicine may cause irreversible heart muscle damage, leading to heart failure. This is more likely to occur if you have other heart problems, have had or currently receiving radiation therapy to your chest, or have received other cancer medicines.
Can doxorubicin cause bradycardia?
Arrhythmia is one of the adverse cardiac effects of doxorubicin, which might be reflected as tachycardia or bradycardia. The heart rate is essential in the diagnosis and evaluation of arrhythmia.