More than 90% of oral and oropharyngeal cancers are squamous cell carcinoma. This means that they begin in the flat, squamous cells found in the lining of the mouth and throat. The most common locations for cancer in the oral cavity are: Tongue.
What genes cause oral cancer?
Here, we analyzed whole-genome sequences of a family with autosomal dominant expression of oral tongue cancer and identified proto-oncogenes VAV2 and IQGAP1 as the primary factors responsible for oral cancer in the family. These two genes are also frequently mutated in sporadic OSCCs and HNSCCs.
What is the most common localization of oral cancer?
The tongue remains the most common site of oral cancer, with 2.5 cases per 100,000 people for the 1994-1998 period.