In terms of how acetanilide is synthesized, it’s most commonly made by reacting aniline with either acetyl chloride or acetic anhydride. Although both methods work equally well, the preparation from acetic anhydride tends to be preferred due to the corrosiveness and toxicity of acetyl chloride. Is acetanilide a phenacetin? AcetaminophenRead More →
water and very soluble in boiling water? acetanilide will dissolve into the heated water due to its high solubility in boiling water but will drop out of solution and crystallize in room temperature water due to its low solubility in cold water. Why is acetanilide partially soluble in water? TheRead More →
Unfortunately, Acetanilide exhibited an unacceptable profile of toxic effects, the most alarming being cyanosis due to methemoglobinemia. … Acetanilide is no longer used as a drug in its own right, although its primary metabolite, paracetamol, has been widely succesful. Is acetanilide a paracetamol? Brodie and Axelrod’s two publications on acetanilideRead More →
Acetylation of aniline results in decrease of electron density on nitrogen hence acetanilide is less basic than aniilne. Why is aniline more basic? On other hands, aniline is also aromatic but the lone pair of electrons of NH2 group in aniline is delocalized over the benzene ring, it is notRead More →