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What medications can cause increased liver enzyme tests (AST and ALT) levels? aspirin, acetaminophen (Tylenol and others), ibuprofen (Advil, Motrin), naproxen (Naprosyn, Naprelan, Anaprox, Aleve), diclofenac (Voltaren, Cataflam, Voltaren-XR), and. phenylbutazone (Butazolidine) What antidepressants cause elevated liver enzymes? The antidepressants associated with greater risks of hepatotoxicity are iproniazid, nefazodone, phenelzine,Read More →