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Antithrombin III inhibits clotting factors IIa (thrombin), Xa, and to a lesser extent IXa and XIIa. UFH and LMWH bind to antithrombin III via a pentasaccharide group, inducing a conformational change which enhances antithrombin-mediated inhibition of these clotting factors. What is the function of antithrombin and heparin? Heparin activates antithrombinRead More →