The fibroblast is one of the most abundant cell types present in the stroma. It has a variety of functions and composes the basic framework for tissues and organs. Under homeostasis, this cell is responsible for maintaining the extracellular matrix (ECM). What layer of skin are fibroblasts found? Dermal fibroblastsRead More →
Human types Fibrillar (Type I, II, III, V, XI) Non-fibrillar. FACIT (Fibril Associated Collagens with Interrupted Triple Helices) (Type IX, XII, XIV, XIX, XXI) Short chain (Type VIII, X) Basement membrane (Type IV) Multiplexin (Multiple Triple Helix domains with Interruptions) (Type XV, XVIII) What is collagen secreted by? Collagen isRead More →
In collagen, glycine is required at every third position, because the assembly of the triple helix puts this residue at the interior (axis) of the helix, where there is no space for a larger side group than glycine’s single hydrogen atom. For the same reason, the rings of the ProRead More →
Collagen glycosylation takes place in the endoplasmic reticulum before triple-helix formation and is mediated by β(1-O)galactosyl- and α(1-2)glucosyltransferase enzymes. What is the difference between procollagen and Tropocollagen? is that procollagen is (biochemistry) the precursor of collagen; it is formed in fibroblasts and converted to collagen by a peptidase while tropocollagenRead More →