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At present, evidence of two major pathways is found. One is that the vesicle is formed on the membrane surface, either at the plasma membrane at the cell surface or at internal cell organelles like the TGN. Another possibility is that vesicles formed elsewhere dock at, fuse with, and thenRead More →

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The secretory pathway of protein synthesis and sorting. Ribosomes synthesizing proteins bearing an ER signal sequence become bound to the rough ER. … Proteins destined to be secreted move by cisternal migration to the trans face of the Golgi and then into a complex network of vesicles termed the trans-GolgiRead More →