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How is sensitization treated? Often used drugs to treat central sensitization include: acetaminophen (paracetamol) – primarily acts centrally reinforcing descending inhibitory pathways. … serotonin- and norepinephrine-reuptake inhibitors – activate noradrenergic descending pathways together with serotonergic pathways. Can Sensitisation be reversed? Given that degradative pathways exist, the process of central sensitizationRead More →