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The normal lung is fully inflated at a transpulmonary pressure of ∼25–30 cmH2O. Consequently, a maximum Pplat, an estimate of the elastic distending pressure, of 30 cmH2O has been recommended. However, overinflation may occur at much lower elastic distending pressures (18–26 cmH2O). Why must transpulmonary pressure be negative? Intrapleural pressureRead More →