Q. What is the pass or fail criteria for friability test? Ans: Generally the test is run for once. If any cracked,cleaved or broken tablets present in the tablet sample after tumbling,the tablets fails the test.
Why is friability test not required for coated tablets?
This is due to avoid tablet to exhibit any unacceptable capping or excessive wear on the tablet edges or logo while undergoing Coating operations.
What does high friability mean?
Friability is the tendency for asbestos containing materials (ACMs) to break down, chip or crumble under pressure or as a result of abrasion. ACMs that are more likely to be damaged, and release inhalable asbestos fibres as a result, are known as ‘friable’.
What is a friability tester?
Used throughout pharmaceutical industry, friability testers measure the difference between the weight of the sample before and after the process in order to check the physical strength of uncoated tablets. Electrolab’s friability testers comply with USP, PH. Eur, and IP specifications.
What is friability test formula?
The formula for friability test use in tablets:
w2= Final weight of tablets or weight after the test.
What causes tablet friability?
Friability is when a tablet has the tendency to chip, crumble or break during transportation. This can happen when the tablet is being handled, packaged or transported and may mean the patient receives an incorrect dose.
What does friability mean in medical terms?
The word “friable” refers to tissue that tears, sloughs, and bleeds more easily when touched. If your cervix tissue becomes overly sensitive and easily irritated, it’s known as a friable cervix.
How many tablets are there in a friability test?
For tablets with a unit weight of more than 650 mg, take a sample of 10 whole tablets. The tablets should be carefully dedusted prior to testing. Accurately weigh the tablet sample, and place the tablets in the drum.
What is limit of friability in IP?
A maximum loss of weight (from a single test or from the mean of the three tests) not greater than 1.0 percent is acceptable for most tablets.
Why is the friability test set at 100 revolutions?
To determine the physical strength of uncoated tablets on exposure to mechanical pressure, Friability test is done. The test can find out the extent of mechanical stress withstandable by the tablets during their manufacturing, distribution and handling processes.
How does a friability tester work?
In friability test, samples are counted and weighted then tumbled in rotating drums with baffles, when the process is stopped; samples are moved out from the instrument, wiped-off dust and weighted again.
What is friability Slideshare?
Friability test: Defined as the % of weight loss by tablets due to mechanical action during the test. … Tablets are weighing before & after testing & friability is expressed as a percentage loss on pre-test tablet weight.
What is friable in pathology?
(frī’ă-bĕl) 1. Said of tissue that readily tears, fragments, or bleeds when gently palpated or manipulated. 2. Easily reduced to powder.
What it means friable?
: easily crumbled or pulverized friable soil.
What is friable mucosa?
Friability describes the ease with which the mucosa is damaged by contact with the endoscope or biopsy instrument. Alterations in mucosal texture are described as increased granularity.
What affects friability?
Other mechanical properties such as friability can be influenced by the amount and type of binder used , the amount and type of lubricant used and the compression force applied .
What is difference between hardness and friability?
Hardness and friability are two terms used to explain physical properties related to the strength of substances. … The main difference between hardness and friability is that hardness is the resistance to scratch or deformation whereas friability is the tendency to crumble.
How do I stop friability on my tablet?
Tablets compressed with extra deep concave punches resulted in lower friability compared with tablets compressed with standard concave or deep concave punches.
What is weight variation test?
In the case of pharmaceutical dosage forms, the weight variation test (also referred to as uniformity of dosage units) is a non-destructive test that compares the individual weights of a sample of tablets with the average weight of the selected sample.
What is disintegration time?
Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions. … In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the drug being solubilized in the media.