DHHS (NIOSH) Publication No.
The format for the 2014 list was revised to include three groups of hazardous drugs: (1) Antineoplastic drugs; (2) Non-antineoplastic hazardous drugs; and (3) Drugs with reproductive effects.
Are antineoplastic drugs hazardous?
Antineoplastic drugs, also known as chemotherapy, cytotoxic and oncology drugs, are used to treat cancer, as well as arthritis, multiple sclerosis, and other non-cancer medical conditions. Most antineoplastic drugs are classified by NIOSH as hazardous drugs.
How do you dispose of mitomycin C?
DISPOSING OF MITOMYCIN C Dispose of MMC container, soaked sponges, and surgical waste materials that have come in contact with MMC (gowns, gloves, patient drapes) in an appropriate chemotherapy disposal container. Wear appropriate Personal Protective Equipment including gloves, mask, face shield and impervious gown.
What happens if you touch mitomycin?
* Contact can irritate the skin and eyes. * High exposure may cause poor appetite, fever, nausea, headache, fatigue and drowsiness. * Repeated contact can cause severe eye damage. * Repeated high exposure may affect the liver, kidneys and blood cells.
What is mitomycin C used for?
Mitomycin-C is an alkylating, anti-tumor antibiotic, generally used in surgery because of its ability to inhibit fibroblast proliferation and suppress vascular ingrowth—two parts of the healing process that can undercut the beneficial effect of a trabeculectomy bleb by producing scarring that stops aqueous outflow.
Why is antineoplastic hazardous?
These include liver and kidney damage, damage to the bone marrow, damage to the lungs and heart, infertility (temporary and permanent), effects on reproduction and the developing fetus in pregnant women, hearing impairment and cancer.
Why are some drugs considered hazardous?
In pharmacology, hazardous drugs are drugs that are known to cause harm, which may or may not include genotoxicity (the ability to cause a change or mutation in genetic material).
Can you share a bathroom with someone on chemo?
If you or a family member is currently receiving chemotherapy, whether in the clinic or at home, it is strongly recommended that precautions be followed in order to keep household members safe: Patients may use the toilet as usual, but close the lid and flush twice. Be sure to wash hands with soap and water.
Is hydroxychloroquine hazardous?
Hydroxychloroquine and chloroquine can cause abnormal heart rhythms such as QT interval prolongation and a dangerously rapid heart rate called ventricular tachycardia.
Why is Klonopin hazardous?
Interference with Cognitive and Motor Performance: Since Klonopin produces CNS depression, patients receiving this drug should be cautioned against engaging in hazardous occupations requiring mental alertness, such as operating machinery or driving a motor vehicle.
Is warfarin a hazardous drug?
* Warfarin is on the Hazardous Substance List because it is regulated by OSHA and cited by ACGIH, DOT, NIOSH, DEP, IRIS and EPA. * This chemical is on the Special Health Hazard Substance List because it is a TERATOGEN.
Is multaq a hazardous drug?
The U.S. Food and Drug Administration (FDA) has completed a safety review of the heart drug Multaq (dronedarone). This review showed that Multaq increased the risk of serious cardiovascular events, including death, when used by patients in permanent atrial fibrillation (AF).
How do you know if a drug is hazardous?
Hazardous Drug: Defined by the American Society of Health System Pharmacists in 1990 as being a drug which displays one or more of the following characteristics: genotoxicity, carcinogenicity, teratogenicity or fertility impairment, or serious organ or other toxic manifestation at low doses in experimental animals or …
How are hazardous drugs classified?
The NIOSH criteria include : carcinogenicity, teratogenicity, reproductive toxicity, genotoxicity, organ toxicity at low doses, and drugs that mimic existing drugs in structure or toxicity. While the majority of the hazardous drugs are cytotoxic antineoplastic drugs, drugs from other classes are included.
Is Methotrexate a hazardous drug?
Methotrexate can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug. For 48 hours after this drug is given, the patient’s body fluids can contain the drug.
Is actemra a hazardous drug?
Potential Health Effects The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation. Compound is Non-hazardous,Non-Toxic/Non-Flammable.
Is oxytocin a hazardous drug?
WARFARIN, OXYTOCIN, CLONAZEPAM—registered
nurses administer millions of these drugs daily with lit- tle awareness that they are hazardous, as defined by the Centers for Disease Control and Prevention/Nation- al Institute for Occupational Safety and Health (CDC/ NIOSH).
What are antineoplastic drugs?
Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.
Which of the following medications is considered an antineoplastic drug?
Antineoplastic agents that are well known to cause significant direct hepatotoxicity when given in moderate to high doses (particularly when used in myeloablation before hematopoietic cell transplantation) include busulfan, melphalan, cyclophosphamide, dacarbazine, cytarabine, fluorouracil, carboplatin and L- …
What is the most common and potentially serious complication of antineoplastic medications?
Many of the medications used to manage the most common toxicities of antineoplastic therapies further alter body functions and can perpetuate a decline in functioning. One of the most common side effects of many antineoplastic drugs therapies is nausea/vomiting (N/V).
Is mitomycin chemotherapy?
Mitomycin is a chemotherapy drug used to treat different cancers including breast, bladder, stomach, pancreatic, anal and lung cancers.
Is mitomycin an antibiotic?
Mitomycin is a type of antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells in your body.
What is mitomycin made from?
Mitomycin is an antitumor antibiotic that is made from a soil fungus called Streptomyces caespitosus. Mitomycin inhibits DNA synthesis by producing DNA cross-links which halt cell replication and eventually cause cell death.